UNESCOMust-see
Trinidad · Itapúa
Misión Jesuítica de la Santísima Trinidad del Paraná
Paraguay's best-preserved Jesuit reduction: reddish stone, musician angels and an evening light show.
398 kmHalf a day
Editorial selection by Asunción City, with data checked in September 2026.
Misiones 34
UNESCOMust-see
Jesús · Itapúa
Misión Jesuítica de Jesús de Tavarangue
A colossal church that was never finished: trefoil arches in the middle of the countryside, a World Heritage Site.
408 km2-3 hours
Must-see
San Cosme y Damián · Itapúa
San Cosme y Damián: misión y Centro de Interpretación Astronómica Buenaventura Suárez
The mission where a Jesuit studied the stars in 1703; today, a planetarium, telescopes and dark skies beside the Paraná.
335 km1 day
Must-see
Humaitá · Ñeembucú
Humaitá: ruinas de la iglesia de San Carlos y la fortaleza
The shell-torn church that became a national symbol, next to the fortress that held back three armies.
270 kmHalf a day
San Ignacio · Misiones
San Ignacio Guazú y su Museo Diocesano de Arte Jesuítico
Paraguay's first Jesuit reduction keeps thirty Guaraní Baroque carvings in a living museum.
226 kmHalf a day
Isla Umbú · Ñeembucú
Isla Umbú: iglesia de San Atanasio y Museo Histórico Coronel Pedro Hermosa
A dairy-farming village with grass streets, a 19th-century adobe church and a museum in the old cabildo, 12 km from Pilar.
242 km2 to 3 hours
Encarnación · Itapúa
Réplica de la estación de ferrocarril de Encarnación y Museo Ferroviario
Replica of the station demolished in 2009 by Yacyretá, housing the Municipal Railway Museum steps from San José beach.
366 km30 to 60 minutes
Santiago · Misiones
Santiago: museo jesuítico y Fiesta de la Tradición Misionera
Jesuit carvings, a complete altarpiece and, every January, the great gaucho festival of Misiones tradition.
278 kmHalf a day
Villa Franca · Ñeembucú
Villa Franca, antigua reducción de los mbokovíes sobre el río Paraguay
One of the country's least populated municipalities, founded in 1775 as a reduction and refounded in 1824 on Francia's orders.
154 km1 to 2 hours
Hohenau · Itapúa
Colonias Unidas: Hohenau y Obligado
Immigrant colonies with community festivals, Choppfest, parks and pioneer museums.
405 km1 day
Carmen del Paraná · Itapúa
Carmen del Paraná
The Rice Capital boasts a riverfront promenade several kilometers long, three beaches and the Tacuary battlefield.
330 km1 day
Coronel Bogado · Itapúa
Coronel Bogado, Capital Nacional de la Chipa
A must-stop on Route PY01: more than thirty chiperías (chipa bakeries), some sixty varieties and ovens fired day and night.
320 km2-3 hours
Ayolas · Misiones
Represa de Yacyretá, Isla Yacyretá y Refugio Atinguy
One of the continent's great hydroelectric dams, with guided tours, a wildlife refuge and an island reserve.
315 kmHalf a day
Santa Rosa · Misiones
Santa Rosa de Lima y la Capilla de Loreto
A Jesuit chapel with Guaraní frescoes and a painted starry ceiling, beside a red-stone bell tower.
245 km2-3 hours
Santa María · Misiones
Santa María de Fe
A peaceful Jesuit town with a Baroque museum, embroidery artisans and howler monkeys in the plaza.
230 kmHalf a day
Pilar · Ñeembucú
Pilar
A historic town on the Paraguay River: the only surviving colonial cabildo, a marble basilica, wetlands and fishing.
230 km2-3 days
Paso de Patria · Ñeembucú
Tuyutí, campo de la batalla del 24 de mayo de 1866
Dry ground ringed by marshes where the largest and bloodiest battle of the Triple Alliance War was fought in 1866.
285 km1 to 2 hours
Yabebyry · Misiones
Yabebyry y sus dos iglesias frente a frente
An 1790 village in the far southwest of Misiones, with an old church and a modern one facing each other.
288 km2 to 3 hours
Encarnación · Itapúa
Catedral de Nuestra Señora de la Encarnación
Seat of the Diocese of Encarnación, built between 1913 and 1938 on the site of earlier 18th and 19th-century churches.
365 km30 to 45 minutes
Encarnación · Itapúa
Plaza de Armas de Encarnación
Heart of Roque González's old Guaraní mission, now a tree-filled square with monuments, ponds and cultural events.
365 km30 to 60 minutes
Encarnación · Itapúa
Molino y Silo San José, patrimonio de la vieja Zona Baja
Two 1940 industrial structures that survived the Yacyretá flooding and can now be seen from San José beach.
366 km20 to 30 minutes
San Pedro del Paraná · Itapúa
San Pedro del Paraná: plaza, casas de adobe y puerta a San Rafael
A village founded in 1789 with adobe houses and timber verandas, and gateway to the San Rafael ridge and reserve.
360 km2 to 3 hours
General Artigas · Itapúa
General Artigas, el pueblo que cambió su nombre por el del prócer uruguayo
Formerly Cangó and Bobí, founded in 1789; in 1942 it took the name of the Uruguayan leader exiled in Paraguay.
360 km1 to 2 hours
San Juan Bautista · Misiones
San Juan Bautista, cuna de Mangoré
The capital of Misiones was the birthplace of guitarist Agustín Pío Barrios, 'Mangoré', and celebrates St John's Day in style.
196 km2-3 hours
Humaitá · Ñeembucú
Curupayty, campo de la batalla de 1866
Where Paraguay's greatest victory of the Great War (the War of the Triple Alliance) was decided along a line of trenches.
280 km2-3 hours
Paso de Patria · Ñeembucú
Paso de Patria
The corner where the Paraguay and Paraná rivers meet: fishing, wetlands and memories of war.
290 km1 day
Guazú Cuá · Ñeembucú
Guazú Cuá y la iglesia de la Inmaculada Concepción
An 1775 village among wetlands with an adobe church opened in 1852 that still has its carved altarpiece.
256 km1 to 2 hours
Laureles · Ñeembucú
Laureles y su plaza yere colonial
A village founded in 1790 that keeps a big square with arcaded colonial houses and the January cattle-country festival.
318 kmHalf a day
General José Eduvigis Díaz · Ñeembucú
General José Eduvigis Díaz e Itá Corá, puerto sobre el Paraná
A cattle town 30 km from Pilar with access to the Paraná at Itá Corá and close to Estero Bellaco, a 1866 battlefield.
262 kmHalf a day
Pirapó · Itapúa
Pirapó, colonia fundada por inmigrantes japoneses
An Itapúa district founded on 2 August 1960 by Japanese immigrants, 7 km off Route 6.
415 km2 to 3 hours
La Paz · Itapúa
Colonia La Paz, comunidad japonesa y paraguaya
A colony founded in the 1958 Japanese wave and made a district in 1986, now shared by Paraguayans and Nikkei.
385 km1 to 2 hours
Capitán Meza · Itapúa
Capitán Meza, colonia alemana y puerto sobre el Paraná
The "mother of districts" of northeastern Itapúa, founded in 1907 by German settlers, with a port on the Paraná.
445 km2 to 3 hours
Mayor José Martínez · Ñeembucú
Mayor José Martínez, pueblo de carretas junto al Estero Bellaco
A southern Ñeembucú village with an old-world feel, Laguna Falcón and Curuzú Abá port, named after a hero killed at Tuyutí.
268 km1 to 2 hours
Natalio · Itapúa
Natalio, el puerto maderero de la época del mensú
A district on a fertile plateau in eastern Itapúa; according to the most likely version, its name comes from a foreman of the 1930s logging camps.
465 km1 to 2 hours